3/7/2024 0 Comments Adrenal cortex medulla![]() This often involves several days of single housing, which can cause numerous logistical problems, as well as cognitive and social dysfunctions. Much of the research done on aging, oxidative stress, anxiety, and cognitive and social behavior in rodents has focused on caloric restriction (CR). Information and insight gained from electrophysiological, molecular biological and imaging (immunocytochemical, freeze fracture, transmission electron microscopic and live-cell) techniques will be provided. Here, we review what is known about gap junctions in the adrenal gland, with particular attention to their role in adrenocortical cell steroidogenesis and proliferation. Knowledge of the factors regulating gap junction-mediated communication and the turnover process are critical to an understanding of adrenal cortical cell functions, including development, hormonal response to adrenocorticotropin (ACTH), and neoplastic de-differentiation. Such communication is regulated by the number of gap junction channels between contacting cells, the rate at which information flows between these channels and the rate of channel turnover. Adrenal cortical steroidogenesis and proliferation are thought to be modulated by gap junction-mediated direct cell-cell communication of regulatory molecules between cells.
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